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Figure 1 | Molecular Pain

Figure 1

From: Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

Figure 1

Example traces for the isolation of ATX-II enhanced TTXs resurgent currents. Representative recordings from one large diameter DRG neuron using the protocol shown in the upper panel in a. (a) Traces recorded under control conditions without any toxin present. (b) Traces recorded with 5nM ATX-II in the extracellular recording solution. (c) shows recordings in the presence of 5 nM ATX-II and TTX with no resurgent currents present. This trace was subsequently subtracted from the ones shown in (a) and (b), revealing the TTXs resurgent current pre (d) and post (e) application of ATX-II, respectively. Eight out of eight large DRGs recorded at 22°C showed resurgent currents.

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Molecular Pain

ISSN: 1744-8069

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