Skip to main content
Figure 4 | Molecular Pain

Figure 4

From: Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

Figure 4

ATX-II induces resurgent currents in small diameter DRGs with the β4-C-terminus peptide in the pipette solution. (a) Voltage protocol (top panel) and representative current traces of recordings from small diameter DRGs with the β4-peptide added to the pipette solution. Lower lane shows an overlay of recordings from control and ATX-II (5 nM) treated cells at −45 mV. (b) TTXs peak current within the first 10 ms after repolarization of control (black symbols, n = 4) and ATX-II exposed (pink symbols, n = 6) small DRGs. Under ATX-II exposure a distinct resurgent current can be recorded, when the β4-peptide is present in the pipette solution. (c) The increase of resurgent current is not due to a persistent current component, as subtraction of the persistent current (determined at the end of the hyperpolarizing pulse, see lower panel in a) from peak current reveals a clear corrected TTXs resurgent current component. * p < 0.05, independent-sample T-test.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us