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Figure 2 | Molecular Pain

Figure 2

From: L type Ca2+ channel blockers prevent oxaliplatin-induced cold hyperalgesia and TRPM8 overexpression in rats

Figure 2

Increase in the intracellular Ca2+ following oxaliplatin or oxalate treatment in primary cultured DRG cells. Oxaliplatin (A: 100-500 μM) or sodium oxalate (B: 100-500 μM) was administered to cultured DRG cells. Nifedipine (C: 10-30 μM), diltiazem (D: 10-30 μM), ethosuximide (E: 1 mM) or mexiletine (F: 100 μ-1 mM) were co-administered with sodium oxalate (500 μM) to cells. Intracellular Ca2+ levels were determined based on Fura-2 fluorescence (340 nm/380 nm). Values are expressed as the mean of 4-8 wells.

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