Figure 6
Reversal of the oxaliplatin-induced increase of TRPM8 mRNA in rat DRG neurons by Ca2+ and Na+ channel blockers. Oxaliplatin (4 mg/kg) was administered i.p. on days 1 and 2. Mexiletine (Mex, 30 mg/kg), nifedipine (Nif, 30 mg/kg) or diltiazem (Dil, 30 mg/kg) was orally co-administered with oxaliplatin. The expression of TRPM8 and G3PDH mRNAs were determined by PCR on day 5. Values are expressed as the mean ± SEM of 5 animals. ††p < 0.01 compared with vehicle group, **p < 0.01 compared with oxaliplatin group.