Figure 4
From: Positive allosteric modulation of TRPV1 as a novel analgesic mechanism
Longitudinal recovery of acute thermal pain sensation following intraplantar MRS1477 + capsaicin. Rats (n = 4) were injected with 2 μg MRS1477 + 30 μg CAP unilaterally and were followed behaviorally for 24 days. Contralateral paws served as the untreated controls. Sensitivity to C-fiber stimulation (A) returned more quickly (by day 14) than did sensitivity to Aδ stimulation (B). * = p < 0.05; ** = p < 0.01; *** = p < 0.001, **** = p < 0.0001. ●2 μg MRS1477 + 30 μg CAP (n = 4). □Contralateral - No Tx (n = 4).