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Figure 2 | Molecular Pain

Figure 2

From: The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy

Figure 2

Time course of development of chemotherapy-induced peripheral neuropathy evoked by cisplatin and paclitaxel treatment. Mechanical (A, B) and cold (C, D) allodynia developed following cisplatin (A, C) or paclitaxel (B, D) treatment. Arrows show timing of injections of chemotherapeutic agents. Data are expressed as mean ± SEM (paclitaxel, n = 76; cremophor, n = 5; cisplatin, n = 36; saline, n = 6). *** P < 0.001, ** P < 0.01, * P < 0.05 vs. vehicle. Non-chemotherapy controls received saline in lieu of cisplatin (A, C) or cremophor vehicle in lieu of paclitaxel (B, D), repeated measures ANOVA and One-way ANOVA at each time point.

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