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Figure 5 | Molecular Pain

Figure 5

From: The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain

Figure 5

Effect of anti-HODE Antibodies and Ketoconazole on LA-evoked Nocifensive Behavior. A. Rats were injected with 1:1CFA and 24 hours later, were injected with either vehicle, control IgG anti-goat antibody or mix of anti-9 and 13-HODE antibodies (25ug each). Following 10 minutes, a second injection of either vehicle or 1000ug LA was given and nocifensive behavior was recorded upto 15 mins. Data plotted is the total nocifensive time (secs) observed between 8 and 15 mins. n = 8/10 was used for each group. Data analyzed using one-way ANOVA with Neuman-Keuls post hoc test. Error Bar: S.E.M. B. Similar to data set 4A, rats were injected with vehicle or 4ug ketoconazole as the first injection into the inflamed paws and 30 minutes later, vehicle or 1000ug LA with vehicle or 1000ug LA with 4ug ketoconazole was given as the second injection. Data plotted is the total nocifensive time (secs) observed between 8 and 15 mins. n = 8/10 was used for each group. Data Analyzed using one-way ANOVA with Neuman-Keuls post hoc test. Error Bar: S.E.M.

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Molecular Pain

ISSN: 1744-8069

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