Homologous desensitization of 15d-PGJ
vs. AITC is dependent on agonist concentration. Homologous sensitization and desensitization are agonist- and concentration-dependent. In contrast to 50 μM 15d-PGJ2 (A), responses to 50 μM AITC sensitize (B) significantly (C). Traces show mean ± SEM of ~30-60 DRG neurons. Values in C represent the peak response of neurons under each condition. **p < 0.01, ***p < 0.001. Data were analyzed using a paired, two-tailed Student’s t-test.