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Figure 3 | Molecular Pain

Figure 3

From: Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD

Figure 3

Enhanced HPA axis inhibition after SPS. (A) During the first 30 min of the 2 hr restraint phase of SPS at day 0, cortisol pretreated rats exhibited a significantly lower ACTH response to restraint compared to control rats that were subjected to SPS in the absence of cortisol injection as determined by repeated measures two-way ANOVA with Sidak’s multiple comparisons test [F(1, 10) = 9.136, p=0.0131] (Veh, vehicle injection. CORT, cortisol injection; n=6 for each group). (B) 9 days after exposure to SPS, cortisol pretreated rats exhibited greater inhibition of ACTH feedback compared to their response during the first restraint in day 0 [F(2, 10) = 6.272, p=0.0172] (n=6). Statistical analysis was carried out by two-way ANOVA with repeated measures (matching both factors) followed by Sidak’s multiple comparisons test (**p<0.005). Data are plotted as mean ± SEM.

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