Figure 4

Temporal Dynamics of SPS-induced mechanical allodynia (A) and thermal hyperalgesia (B). Rat PWT to von Frey stimuli (control: n = 12–24, SPS: n = 11–22) and paw withdrawal latency (PWL) to radiant heat (control: n = 9–22, SPS: n = 9–20) dramatically decreased as early as 7 days after SPS and lasted the length of the study, 28 days. Sensitivity in each paw differed significantly from its pre-SPS threshold; ^ΔΔ p<0.01) and from corresponding controls (*p<0.01; **p<0.001). Statistical analysis was carried out by two-way ANOVA followed by Sidak’s multiple comparisons test. Data plotted as mean ± SEM.