Figure 5
From: Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD
SPS increased N/OFQ levels in CSF (A) and serum (B). Serum and CSF were collected on day 9, 14 and 28 after SPS. N/OFQ level was elevated in CSF at day 9 (control: n = 4; SPS, n = 10. **p< 0.01), 14 (control: n = 8; SPS, n = 8. *p<0.05) and 28 (control: n=9; SPS, n = 7, **p<0.01). Serum N/OFQ level was elevated at day 28 (control: n = 12; SPS, n = 10. **p<0.01), but not day 9 (n=4 for control; n=10 for SPS) or 14 (n = 6/group). Statistical analysis was carried out by unpaired Student’s t-test. Data are plotted as mean ± SEM.