Changes in xCT and AGS3 levels in the lumbar spinal cord of mice developing neuropathic pain. Immunoblot analysis of mGlu2/3 receptors, xCT, and AGS3 in the ipsilateral (ipsi) and contralateral (ctl) dorsal portions of the lumbar spinal cord of sham operated animals (SO) and CCI mice is shown in (A), (B), and (C), respectively. AGS3 mRNA levels in the ipsilateral and contralateral DRG are shown in (D). Values are means ± S.E.M. of 6–8 individual determinations (from 2 groups of 8 mice). In (B), p < 0.05 (Two-way ANOVA + Holm-Sidak’s test) vs. the respective values of SO mice (*), or vs. values of the ipsilateral side of CCI mice (#).