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Figure 2 | Molecular Pain

Figure 2

From: Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Figure 2

Inhibition of NK1-R in the RVM attenuates inflammatory bilateral hyperalgesia. Intra-RVM microinjection of NK1-R antagonists attenuates CFA-induced bilateral hyperalgesia. CFA (0.05 ml; 1:1 oil/saline) was injected unilaterally into the masseter muscle 24 h prior to RP67580 (A, B) and L-733,060 (C, D) microinjection into the RVM (0.5 μl). +: lowest dose vs. saline. #: middle dose vs. saline. *: highest dose vs. saline. +,#,*: p<;0.05; ++,##,**: p<;0.01; +++,###,***: p<;0.001 (ANOVA with repeated measures and Student Neuman-Keuls post-hoc test).

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Molecular Pain

ISSN: 1744-8069

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