Figure 3

Inhibition of NK1-R in the RVM attenuates IL-1β-induced bilateral hyperalgesia. Intra-RVM microinjection of NK1-R antagonists attenuates intra-Vi/Vc IL-1β-induced bilateral hyperalgesia. IL-1β (160 fmol/0.5 μl) was microinjected unilaterally into the Vi/Vc 15 min prior to RP67580 (A, B) and L-733,060 (C, D) microinjection into the RVM (0.5 μl). +: lowest dose vs. saline. #: middle dose vs. saline. *: highest dose vs. saline. +,#,*: p<;0.05; ++,##,**: p<;0.01; +++,###,***: p<;0.001 (ANOVA with repeated measures and Student Neuman-Keuls post-hoc test).