Figure 6
From: Sensory discrimination between innocuous and noxious cold by TRPM8-expressing DRG neurons of rats
Changes of membrane and action potential parameters during cooling in TTXs/TRPM8 and TTXr/TRPM8 DRG neurons. A-D) Scatter plots of membrane and action potential parameters of 9 individuals TTXs/TRPM8 cells during cooling ramps. E-H) Scatter plots of membrane and action potential parameters of 7 individual TTXr/TRPM8 cells during cooling ramps. In each experiment, a slow ramp of cooling temperatures was started at 29°C. Different cells are shown in different colors (symbols). Black lines in each panel were best fit for each category from one TTXs/TRPM8 and one TTXr/TRPM8 cell chosen to best represent each group. Cold/menthol-sensitive cells were pre-identified with calcium imaging before current-clamp experiments. Scatter plots are used to present the changes of these parameters during cooling because the temperatures at which action potential firing started and ended were not exactly the same among these cells.