Intrathecal administration of PAF receptor antagonist (WEB2086) significantly reduces the mechanical allodynia following peripheral nerve injury. (A, B) The osmotic pump was set 2 days after nerve injury and drug administration continued for 7 days. (C, D) The osmotic pump was implanted 6 days after SNI surgery and worked for 7 days. (B, D) The treatment with these drugs did not change the mechanical sensitivity on the contralateral side. In all graphs, values are mean ± SEM (n = 6-7 in each group, # p < 0.05 compared with vehicle).