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Figure 5 | Molecular Pain

Figure 5

From: Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury

Figure 5

Intrathecal administration of PAF receptor antagonist (WEB2086) did not affect on the microglia activation and phosphorylation of p38 MAPK following peripheral nerve injury. (A-C) Immunohistochemistry of Iba1 in the spinal cord of rats that received chronic administration of saline (A, B) and WEB2086 (C) in the contralateral (A) and ipsilateral side (B, C) of dorsal horn at 3 days after SNI surgery. (D-F) Immunohistochemistry of p-p38 in the spinal cord of SNI model rats with saline (D, E) and WEB2086 (F) administration in the contralateral (D) and ipsilateral side (E, F) of dorsal horn at 3 days after SNI surgery. (G-J) Western blot analysis of p-p38 MAPK in the spinal cord after peripheral nerve injury. (G, H) Immunoreactive membrane panels show p-p38 MAPK in the L4, 5 spinal cords at 3 days (G) and 7 days after injury (H). (I, J) Graph shows the protein levels of p-p38 expressed as percentages of the protein level in the normal control spinal cord (mean ± SEM; each time points n = 4,). * indicates p < 0.05 (ANOVA) compared to naïve control.

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