Figure 1From: Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy In vivo mechanical hypersensitivity following nerve injury. Measurements were performed with von Frey hairs applied to the plantar (A) and dorsal (B) surfaces of hind paws, before and 2 weeks after CCI or sham operation on the saphenous nerve. *P < 0.05, compared to thresholds before injury, thresholds of contralateral paws of CCI animals, and of both hind paws of sham-operated animals (2-way RM ANOVA, Bonferroni t test). Data are expressed as means ± SEM. N = 6 mice per group.Back to article page