In vivo mechanical hypersensitivity following nerve injury. Measurements were performed with von Frey hairs applied to the plantar (A) and dorsal (B) surfaces of hind paws, before and 2 weeks after CCI or sham operation on the saphenous nerve. *P < 0.05, compared to thresholds before injury, thresholds of contralateral paws of CCI animals, and of both hind paws of sham-operated animals (2-way RM ANOVA, Bonferroni t test). Data are expressed as means ± SEM. N = 6 mice per group.