|
Fibre type
|
Group
|
Uninjured nerves
|
Injured nerves
|
|---|
| | |
Numbers
|
Baseline (g)
|
DAMGO (g)
|
Numbers
|
Baseline (g)
|
DAMGO (g)
|
|---|
|
Aβ
|
All fibres
|
n = 68
|
0.14 ± 0.02
|
0.15 ± 0.02
|
n = 46
|
0.11 ± 0.02
|
0.11 ± 0.02
|
| |
DAMGO-responders
|
n = 2
|
0.22 ± 0.09
|
0.42 ± 0.12
|
n = 0
|
-
|
-
|
| |
DAMGO-nonresponders
|
n = 66
|
0.14 ± 0.02
|
0.14 ± 0.02
|
n = 46
|
0.11 ± 0.02
|
0.11 ± 0.02
|
|
Aδ
|
All fibres
|
n = 65
|
0.35 ± 0.05
|
0.38 ± 0.05
|
n = 93
|
0.40 ± 0.04
|
0.65 ± 0.08 *
|
| |
DAMGO-responders
|
n = 4
|
0.25 ± 0.11
|
0.69 ± 0.13
|
n = 28
|
0.38 ± 0.06
|
1.19 ± 0.23
|
| |
DAMGO-nonresponders
|
n = 61
|
0.35 ± 0.05
|
0.35 ± 0.05
|
n = 65
|
0.44 ± 0.07
|
0.44 ± 0.07
|
|
C
|
All fibres
|
n = 19
|
0.61 ± 0.14
|
0.72 ± 0.17
|
n = 39
|
0.64 ± 0.09
|
1.03 ± 0.18 *
|
| |
DAMGO-responders
|
n = 3
|
0.98 ± 0.15
|
1.69 ± 0.40
|
n = 18
|
0.70 ± 0.13
|
1.56 ± 0.31
|
| |
DAMGO-nonresponders
|
n = 16
|
0.54 ± 0.15
|
0.54 ± 0.15
|
n = 21
|
0.59 ± 0.12
|
0.59 ± 0.12
|
- DAMGO was applied at a concentration of 100 μM. N represents the number of fibres, and g refers to the fibre thresholds. *P < 0.05, compared to the respective baseline thresholds (Wilcoxon test). No statistical evaluation was performed for DAMGO-responders or DAMGO-nonresponders in uninjured or injured nerves. In uninjured nerves, the number of fibres from sham-operated and nonoperated nerves is the same as in Figure 2. Data are expressed as means ± SEM.
