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Table 1 Effects of DAMGO on mechanical thresholds of sensory fibres in uninjured and injured nerves

From: Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy

Fibre type    Group Uninjured nerves Injured nerves
   Numbers Baseline (g) DAMGO (g) Numbers Baseline (g) DAMGO (g)
All fibres n = 68 0.14 ± 0.02 0.15 ± 0.02 n = 46 0.11 ± 0.02 0.11 ± 0.02
  DAMGO-responders n = 2 0.22 ± 0.09 0.42 ± 0.12 n = 0 - -
  DAMGO-nonresponders n = 66 0.14 ± 0.02 0.14 ± 0.02 n = 46 0.11 ± 0.02 0.11 ± 0.02
All fibres n = 65 0.35 ± 0.05 0.38 ± 0.05 n = 93 0.40 ± 0.04 0.65 ± 0.08 *
  DAMGO-responders n = 4 0.25 ± 0.11 0.69 ± 0.13 n = 28 0.38 ± 0.06 1.19 ± 0.23
  DAMGO-nonresponders n = 61 0.35 ± 0.05 0.35 ± 0.05 n = 65 0.44 ± 0.07 0.44 ± 0.07
C All fibres n = 19 0.61 ± 0.14 0.72 ± 0.17 n = 39 0.64 ± 0.09 1.03 ± 0.18 *
  DAMGO-responders n = 3 0.98 ± 0.15 1.69 ± 0.40 n = 18 0.70 ± 0.13 1.56 ± 0.31
  DAMGO-nonresponders n = 16 0.54 ± 0.15 0.54 ± 0.15 n = 21 0.59 ± 0.12 0.59 ± 0.12
  1. DAMGO was applied at a concentration of 100 μM. N represents the number of fibres, and g refers to the fibre thresholds. *P < 0.05, compared to the respective baseline thresholds (Wilcoxon test). No statistical evaluation was performed for DAMGO-responders or DAMGO-nonresponders in uninjured or injured nerves. In uninjured nerves, the number of fibres from sham-operated and nonoperated nerves is the same as in Figure 2. Data are expressed as means ± SEM.