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Figure 1 | Molecular Pain

Figure 1

From: Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn

Figure 1

Expression of Nav1.7 in DRG neurons. A. DRG sections were reacted to antibodies against peripherin, neurofilament 200 (NF) and Nav1.7. Peripherin-positive (green) neurons are generally of small diameter (<30 μm) and most exhibit colocalization (yellow) with Nav1.7 (red). A few small peripherin-negative neurons display robust Nav1.7 immunolabeling (arrows). Neurofilament 200 (NF)-positive (blue) neurons are generally larger than peripherin-positive cells and most do not display colocalization with Nav1.7. A few smaller NF-positive cells exhibit Nav1.7 immunolabeling (magenta). B. DRG sections were reacted with IB4-488 and antibodies to CGRP and Nav1.7. Virtually all IB4-positive (green) neurons display colocalization (yellow) with Nav1.7. Similarly, nearly all CGRP-positive (blue) neurons exhibit colocalization (magenta) with Nav1.7 (red). Few DRG neurons (arrow) display colocalization of IB4, CGRP and Nav1.7.

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Molecular Pain

ISSN: 1744-8069

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