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Figure 4 | Molecular Pain

Figure 4

From: Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn

Figure 4

Expression of Nav1.7 in dorsal and ventral roots. A., B. Sections of dorsal (A) and ventral (B) roots were reacted with antibodies to peripherin, neurofilament 200 (NF) and Nav1.7. Numerous peripherin-positive (green) fibers are present in dorsal root but few in ventral root. There is extensive colocalization (yellow) of peripherin (green) and Nav1.7 in dorsal root fibers. Ventral roots do not exhibit detectable Nav1.7 labeling. C., D. Both dorsal (C) and ventral (D) roots display caspr paranodal labeling (green). Nav1.7 (red) immunolabeling is displayed by small diameter fiber in dorsal root but not in ventral root. Inset. Increased magnification of nodal region demonstrates that Nav1.7 labeling is confined to node.

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Molecular Pain

ISSN: 1744-8069

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