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Figure 6 | Molecular Pain

Figure 6

From: Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn

Figure 6

Nav1.7 is expressed in pre-synaptic fibers in dorsal horn. A. Synaptophysin (green), a marker of synapses, exhibits prominent labeling in the dorsal horn. Nav1.7 (red) and synaptophysin display extensive colocalization in the superfical layers of the dorsal horn. Inset. Increased magnification of superfical lamina of dorsal horn demonstrates colocalization of synaptophysin and Nav1.7. B. NeuN (green) immunolabels nuclei and cell bodies of neurons in dorsal horn. Post-synaptic neurons in the superficial lamina exhibit a lack Nav1.7 (red) labeling, which is localized in extracellular regions to the post-synaptic neurons. Right inset: increased magnification demonstrating lack of Nav1.7 immunoreactivity (red) within NeuN-labeled (green) dorsal horn neuronal cell bodies. Left inset: NeuN-labeled motor neurons (green) in ventral horn lack Nav1.7 immunolabeling (red).

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Molecular Pain

ISSN: 1744-8069

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