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Figure 6 | Molecular Pain

Figure 6

From: JAK-STAT1/3-induced expression of signal sequence-encoding proopiomelanocortin mRNA in lymphocytes reduces inflammatory pain in rats

Figure 6

CRF-induced antinociception in recipients of activated, ConA/IL-4-stimulated T cells is opioid mediated. A) NLX reversibility of CRF-induced antinociception in CTX-treated recipients of T cells stimulated with ConA/IL-4. PPT were determined at baseline and after i.pl. injections of T cells and CRF. Controls received s.c. NaCl. B) CRF-induced antinociception and NLX-reversibility in non-immunosuppressed rats. PPT were determined at baseline and after CRF injection. Data represent means ± SD (n = 7–8 animals per group). Effects of the injection (baseline versus CRF) and of the treatment (saline versus NLX) on ipsilateral PPT were analyzed using Two-Way RM ANOVA and Bonferroni’s Test. §§§, CRF injection significantly elevated PPT in NaCl-treated animals (P < 0.001); ***, CRF-induced elevation of PPT is significantly reduced by NLX (P < 0.001).

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Molecular Pain

ISSN: 1744-8069

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