Figure 4From: p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI) Representative images of p300 immunoreactivity in rats’ spinal dorsal horn among different groups . p300 immunoreactivity was mainly located in the nucleus but not in the cytoplasm. Representative p300-positive cells were pointed by arrows (Scale bars = 50um); basal p300 expression in sham-operated rats (A), CCI-induced overexpression of p300 in NS-treated rats (B), NC-treated rats (C), C37-treated rats (E) and C646-treated rats (F), p300 shRNA moderately decreased the p300 expression in LV-shp300-treated CCI rats (D).Back to article page