Figure 5From: p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI) ChIP assays in shRNA treated and p300 acetyltransferase inhibitor treated rats . Reactions were performed with normal mouse IgG or anti-p300 antibodies. Real time PCR was used to quantify the enrichment of p300 promoter region of the cox-2 gene. Comparison between rats with different treatments: *P < 0.05 vs. sham-operated group; #P < 0.05 vs. NS and NC-treated groups. ΔP < 0.05 vs. C37-treated group. S: sham-operated rats; NS: NS-treated CCI rats; NC: LV-NC-treated CCI rats; shp300: LV-shp300-treated CCI rats. C37: C37-treated CCI rats; C646:C646-treated CCI rats.Back to article page