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Figure 6 | Molecular Pain

Figure 6

From: p300 exerts an epigenetic role in chronic neuropathic pain through its acetyltransferase activity in rats following chronic constriction injury (CCI)

Figure 6

The effects of intrathecal injections of p300 shRNA and p300 acetyltransferase inhibitor on COX-2 expression . A: Expression of COX-2 mRNA in the lumbar spinal cord in all rats. Typical results are shown. B: The mean (±SEM) of IOD of COX-2/β-actin in all rats on mRNA level, n = 5; C: Expression of protein COX-2 in the lumbar spinal cord in all rats. Typical results are shown. D: The mean (±SEM) of IOD of COX-2/β-actin in all rats on protein level, n = 5. S: sham-operated rats; NS: NS-treated CCI rats; NC: LV-NC-treated CCI rats; shp300: LV-shp300-treated CCI rats. C37: C37-treated CCI rats; C646: C646-treated CCI rats. *P < 0.05 vs. sham-operated group; #P < 0.05 vs. NS and NC-treated groups. ΔP < 0.05 vs. C37-treated group.

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Molecular Pain

ISSN: 1744-8069

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