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Table 1 μCT skeletal morphology of the ipsilateral femurs in the control and tibia fractured (FX) wild type and SP deficient mice at 3 weeks post-injury

From: Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome

 

Wildtype mice

SP deficient mice

Control

FX

MPD

Control

FX

MPD

Distal femur

      

  BV/TV (%)

22.8 ± 0.7

13.4 ± 0.8

−41.2%***

22.3 ± 1.3

13.9 ± 0.5

−37.7%***

  TbN (mm-1)

5.1 ± 0.1

4.6 ± 0.1

−9.8%***

5.3 ± 0.1

4.7 ± 0.1

−11.3%***

  TbTh (μm)

58.5 ± 0.5

47.6 ± 0.7

−18.6%***

54.7 ± 1.6

46.6 ± 0.5

−14.8%***

  TbSp (μm)

185 ± 3

209 ± 5

13.0%***

177 ± 4

203 ± 3

14.7%***

  ConnD (1/mm3)

156 ± 7

106 ± 8

−32.1%***

181 ± 6

125 ± 5

−30.9%***

Middle femur

      

  BAr (mm2)

1.04 ± 0.01

0.90 ± 0.02

13.5%***

0.97 ± 0.04

0.85 ± 0.02

12.4%*

  TtAr (mm2)

2.22 ± 0.04

2.22 ± 0.06

0

2.11 ± 0.07

2.12 ± 0.05

0.5%

  MeAr (mm2)

1.18 ± 0.03

1.32 ± 0.06

11.9%*

1.14 ± 0.04

1.27 ± 0.04

11.4%*

  CtTh (μm)

224 ± 2

189 ± 5

−15.6%***

211 ± 5

185 ± 4

−12.3%***

  BPm (mm)

9.9 ± 0.1

10.3 ± 0.2

4.0%

9.8 ± 0.2

10.0 ± 0.1

2.0%

  BAr/TtAr (%)

47.0 ± 0.4

40.7 ± 1.1

13.4%***

45.9 ± 0.4

40.3 ± 0.8

12.2%***

  1. The changes of trabecular and cortical bone parameters in wild type and SP-deficient mice are expressed as the Mean Percent Difference (MPD). MPD = ((FX - Control)/Control) × 100. Bold font indicates statistically significant differences in MPD between FX and age-matched controls for both wild type and SP deficiency mice, as determined by Students’ t-test (mean ± SE, *p < 0.05, **p < 0.01 and ***p < 0.001).
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Molecular Pain

ISSN: 1744-8069

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