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Table 1 μCT skeletal morphology of the ipsilateral femurs in the control and tibia fractured (FX) wild type and SP deficient mice at 3 weeks post-injury

From: Neuropeptide deficient mice have attenuated nociceptive, vascular, and inflammatory changes in a tibia fracture model of complex regional pain syndrome

  Wildtype mice SP deficient mice
Control FX MPD Control FX MPD
Distal femur       
  BV/TV (%) 22.8 ± 0.7 13.4 ± 0.8 −41.2%*** 22.3 ± 1.3 13.9 ± 0.5 −37.7%***
  TbN (mm-1) 5.1 ± 0.1 4.6 ± 0.1 −9.8%*** 5.3 ± 0.1 4.7 ± 0.1 −11.3%***
  TbTh (μm) 58.5 ± 0.5 47.6 ± 0.7 −18.6%*** 54.7 ± 1.6 46.6 ± 0.5 −14.8%***
  TbSp (μm) 185 ± 3 209 ± 5 13.0%*** 177 ± 4 203 ± 3 14.7%***
  ConnD (1/mm3) 156 ± 7 106 ± 8 −32.1%*** 181 ± 6 125 ± 5 −30.9%***
Middle femur       
  BAr (mm2) 1.04 ± 0.01 0.90 ± 0.02 13.5%*** 0.97 ± 0.04 0.85 ± 0.02 12.4%*
  TtAr (mm2) 2.22 ± 0.04 2.22 ± 0.06 0 2.11 ± 0.07 2.12 ± 0.05 0.5%
  MeAr (mm2) 1.18 ± 0.03 1.32 ± 0.06 11.9%* 1.14 ± 0.04 1.27 ± 0.04 11.4%*
  CtTh (μm) 224 ± 2 189 ± 5 −15.6%*** 211 ± 5 185 ± 4 −12.3%***
  BPm (mm) 9.9 ± 0.1 10.3 ± 0.2 4.0% 9.8 ± 0.2 10.0 ± 0.1 2.0%
  BAr/TtAr (%) 47.0 ± 0.4 40.7 ± 1.1 13.4%*** 45.9 ± 0.4 40.3 ± 0.8 12.2%***
  1. The changes of trabecular and cortical bone parameters in wild type and SP-deficient mice are expressed as the Mean Percent Difference (MPD). MPD = ((FX - Control)/Control) × 100. Bold font indicates statistically significant differences in MPD between FX and age-matched controls for both wild type and SP deficiency mice, as determined by Students’ t-test (mean ± SE, *p < 0.05, **p < 0.01 and ***p < 0.001).