Figure 1

Abilities of essential oils to activate hTRPM8 or hTRPA1. (A, B) Comparison of the effects of essential oils (0.01 wt%) on hTRPM8 (n = 34–134) (A) or hTRPA1 (n = 16–67) (B) using a Ca²⁺-imaging method with HEK293T cells expressing hTRPM8 or hTRPA1. Fura-2 ratio (340/380 nm; cytosolic Ca²⁺ concentrations) increases by each oil were normalized to the fura-2 ratio increases by 1 mM menthol. (C) The Ratio of hTRPM8-activating ability versus hTRPA1-activating ability by dividing the values in (A) by the values in (B).