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Figure 3 | Molecular Pain

Figure 3

From: Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain

Figure 3

Numbers of microglia (CD45lo CD11b+ ) in lumbar spinal cord following L5Tx in WT, CD4KO, and CD40KO mice. Total mononuclear cells collected as described in Figure 2 were analyzed for their microglial content. The temporal changes of the numbers of lumbar spinal cord microglia in WT (A, n = 5–8), CD4 KO (B, n = 4) and CD40 KO (C, n = 4) mice are shown here (mean ± SEM). One-way ANOVA was performed to examine the basal level genotypic differences among naïve mice and no significant differences were found. Two-way ANOVA for data sets in each graph were performed. * indicates significant differences between the indicated group and all other groups at the same time point. # indicates significant differences between the indicated group and all other groups within the same treatment group (including the corresponding Day 0 group). #1 indicates significant differences between the indicated group and days 0, 1 and 14 groups within the same treatment group. An additional significant result from statistical comparison is also shown within the graph. “Tx” = L5Tx, “Sh” = sham operation, “ipsi” = ipsilateral side, and “contra” = contralateral side. For naïve mice, “ipsi” = left and “contra” = right

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Molecular Pain

ISSN: 1744-8069

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