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Figure 2 | Molecular Pain

Figure 2

From: P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons

Figure 2

High P2X3R-mediated activity in DRG neurons of immature rats. (A) α,β-meATP induced significant depolarizations in DRG neurons of immature rats. In this example, α,β-meATP evoked 8.6 mV depolarization in a P4 DRG neuron. The depolarization was reversibly blocked by the P2X antagonist, TNP-ATP (1 μM). (B) α,β-meATP induced a much reduced, i.e., 2 mV, depolarization in an adult DRG neuron. (C) The percentage of DRG neurons responded to α,β-meATP was high in immature rats and greatly reduced in adult rats (P3-P14 rats: 55.0%, adult rats: 15.4%. Fisher exact test, *P < 0.05). The amplitude of depolarizations induced by α,β-meATP was reduced as rats matured (P3-P14 rats: 7.0 ± 0.8 mV, n = 11; adult rats: 2.0 ± 0 mV, n = 2. Mann-Whitney test, *P < 0.05)

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