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Figure 4 | Molecular Pain

Figure 4

From: P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons

Figure 4

P2X7R-P2X3R inhibitory control exists in immature rats. (A) P2X7R-siRNA treatment down-regulated P2X7R expression while increased P2X3R expression in P15-16 rats. P2X3R and P2X7R expressions in P2X7R-siRNA rats were expressed in relative intensity with respect to those in Con-siRNA rats, which was set at 1.0. (B) The α,β-meATP induced much more pronounced P2X3R-mediated flinching responses in con-siRNA immature rats than in adult rats. In both immature and adult rats, α,β-meATP evoked significantly larger flinching responses in P2X7R-siRNA rats than in con-siRNA rats.

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Molecular Pain

ISSN: 1744-8069

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