Figure 5From: No evidence for the development of acute analgesic tolerance during and hyperalgesia after prolonged remifentanil administration in miceEffect of a prolonged (3 h) and tapered remifentanil infusion on thermal thresholds measured by plantar test. The infusion was started at a rate of 240 mg/kg/h that was reduced to 180 mg/kg/h at 30 min and continued at 120 mg/kg/h at 60 min until the end of the infusion. The data are expressed as the mean ± SEM, n = 6. *P < 0.05 vs. baseline (one-way ANOVA followed by Dunnett’s test).Back to article page