Figure 7

BDNF regulation of aPKCs at central synapses. Summary cartoon of major findings presented here. At spinal synapses, BDNF activated trkB leading to increased PI3K and PDK1 activity. This stimulates aPKC phosphorylation at T410 and an increase in AKT activity thereby stimulating mTORC1. This increase in mTORC1 activity leads to an increase in eIF4F complex formation resulting in an enhancement of aPKC translation at spinal synapses. Data from cortical SNS preparations strongly suggest that this signaling complex engaged by BDNF resulting in regulation of PKMζ is present across central synapses.