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Figure 5 | Molecular Pain

Figure 5

From: Intervention of electroacupuncture on spinal p38 MAPK/ATF-2/VR-1 pathway in treating inflammatory pain induced by CFA in rats

Figure 5

Effect of EA on p-ATF-2 expression in the ipsilateral spinal dorsal horn at 14 day after CFA injection. A-E. Immunohistochemistry shows p-ATF-2 IR cells in the L4-6 ipsilateral spinal cord dorsal horn of Control rats (A), CFA rats (B), CFA+EA rats (C) and CFA+Sham EA rats (D) at 14 day after CFA injection. F. Quantification of p-ATF-2 IR shows that EA suppresses p-ATF-2 IR cells in the L4-6 ipsilateral spinal dorsal horn on 14 day after CFA injection. **P<0.01 vs. group Control. ▲ ▲ P<0.01 vs. group CFA. ● ● P<0.01 vs. group CFA+Sham EA. n=3-5. Scale bars: 100 μm, section thickness: 30 μm. F, G. Western blotting analysis reveals that EA suppresses p-ATF-2 protein in the L4-6 ipsilateral spinal dorsal horn at 14 day after CFA injection. F. Quantification of G. p-ATF-2 protein in normalized against β-actin. n=4-6, *P<0.05, **P<0.01 vs. group Control. ▲ P<0.05 vs. group CFA. ● P<0.05 vs. group CFA+Sham EA.

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Molecular Pain

ISSN: 1744-8069

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