Figure 3
Comparison of the L-type and R-type high voltage activated Ca2+currents (HAV) of DiI+DRG neurons from control and TNBS treated rats. (A) Examples of the current traces (upper row) and the time course (lower row) with differrent calcium channel blockers on I Ba in colonic specific DRG neurons of control group (left, capacitance = 23.3 PF) and TNBS group (Right, capacitance = 24.8 PF). Currents were elicited by depolarizing neurons from −60 to 0 mV for 240 ms. (B) Changes of the current density of L-type and R-type current. The Bar graphs show that the density of L-type current (−38.56 ± 3.97 pA/pF Vs −25.75 ± 3.35 pA/pF, n = 9 for each group, * P < 0.05) and R-type current (−13.31 ± 1.36 pA/pF Vs −8.60 ± 1.25 pA/pF, n = 9 for each group, *P < 0.05) significantly increased in colonic specific DRG neurons of TNBS group compared with control group.