Table 1 List of the strongly regulated genes in DRGs of TNBS treated rats

Channels

AY323810

Cacna1c

calcium channel, voltage-dependent, L type, alpha 1C subunit

18.45 ± 1.62

NM_019294

Cacna1e

calcium channel, voltage-dependent, L type, alpha 1E subunit

14.82 ± 1.51

XM_341818

Ryr1

ryanodine receptor 1, skeletal muscle

13.50 ± 1.23

NM_012825

Aqp4

aquaporin 4

10.26 ± 1.21

NM_019256

P2rx7

purinergic receptor P2X, ligand-gated ion channel, 7

3.75 ± 0.81

XM_233477

Kcnq4

potassium voltage-gated channel, subfamily Q, member 4

3.03 ± 0.57

XM_344426

Kctd9

potassium channel tetramerisation domain containing 9

2.76 ± 0.32

NM_017261

Gria2

glutamate receptor, ionotropic, AMPA2

2.47 ± 0.29

NM_017303

Kcnab1

Potassium voltage-gated channel, shaker-related subfamily, beta member 1

2.25 ± 0.27

NM_031046

Itpr2

inositol 1,4,5-triphosphate receptor 2

2.17 ± 0.25

AI407979

Fxyd5

FXYD domain-containing ion transport regulator 5

0.46 ± 0.04

NM_053870

Kcnj4

potassium inwardly-rectifying channel, subfamily J, member 4

0.44 ± 0.05

AF313481

Trpc3

transient receptor potential cation channel, subfamily C, member 3

0.27 ± 0.04

Receptor

NM_012585

Htr1a

5-hydroxytryptamine (serotonin) receptor 1A

9.87 ± 1.32

NM_012675

Tnf

tumor necrosis factor (TNF superfamily, member 2)

8.94 ± 1.21

M64867

Htr2a

5-hydroxytryptamine (serotonin) receptor 2A

5.12 ± 0.98

NM_053429

Fgfr3

fibroblast growth factor receptor 3

4.81 ± 0.84

NM_001002853

P2ry13

purinergic receptor P2Y, G-protein coupled, 13

2.92 ± 0.45

BC087035

Tgfbr1

transforming growth factor, beta receptor 1

2.68 ± 0.46

NM_001013032

Npy1r

neuropeptide Y receptor Y1

2.31 ± 0.30

NM_031569

Oprl1

opioid receptor-like 1

2.26 ± 0.23

NM_031088

Ptger2

prostaglandin E receptor 2, subtype EP2

2.26 ± 0.25

NM_053552

Tnfsf4

tumor necrosis factor (ligand) superfamily, member 4

2.15 ± 0.14

NM_012800

P2ry1

purinergic receptor P2Y, G-protein coupled 1

2.10 ± 0.10

XM_217136

Cd3g

CD3 antigen, gamma polypeptide

0.47 ± 0.05

NM_019198

Fgf17

fibroblast growth factor 17

0.42 ± 0.06

NM_138880

Ifng

interferon gamma

0.36 ± 0.04

NM_053680

Insl3

insulin-like 3

0.02 ± 0.01

Signal transduction-related molecules

AW526572

RragB

Ras-related GTP binding B

12.28 ± 1.89

XM_220933

Arf4l

ADP-ribosylation factor 4-like

6.06 ± 0.64

XM_343450

Rasa2

RAS p21 protein activator 2

4.44 ± 0.41

NM_133392

Stk17b

serine/threonine kinase 17b (apoptosis-inducing)

3.13 ± 0.30

NM_031622

Mapk6

mitogen-activated protein kinase 6 (ERK 3)

3.00 ± 0.34

XM_236242

Rab39

RAB39, member RAS oncogene family

2.73 ± 0.31

NM_134346

Rap1b

RAS related protein 1b

2.69 ± 0.36

NM_031130

Nr2f1

nuclear receptor subfamily 2, group F, member 1

2.59 ± 0.29

XM_342223

Prkci

protein kinase C, iota

2.46 ± 0.26

NM_022692

Rab5a

RAB5A, member RAS oncogene family

2.36 ± 0.26

XM_225020

Rasa3

RAS p21 protein activator 3

2.34 ± 0.24

XM_341399

Mapk8

mitogen-activated protein kinase 8 (JNK 1)

2.33 ± 0.28

NM_053522

Rhoq

ras homolog gene family, member Q

2.19 ± 0.18

M83679

Rab15

RAB15, member RAS onocogene family

2.17 ± 0.16

NM_021763

Arfip1

ADP-ribosylation factor interacting protein 1

2.14 ± 0.14

NM_053306

Pak2

p21 (CDKN1A)-activated kinase 2

2.07 ± 0.10

XM_232732

Map3k6

mitogen-activated protein kinase kinase kinase 6

0.49 ± 0.04

BF403410

Camk2b

Calcium/calmodulin-dependent protein kinase II, beta

0.46 ± 0.04

NM_031716

Wisp1

WNT1 inducible signaling pathway protein 1

0.45 ± 0.04

NM_133568

Rasd2

RASD family, member 2

0.38 ± 0.05

XM_215821

Usp8

ubiquitin specific protease 8

0.36 ± 0.04

AA945841

Rab10

RAB10, member RAS oncogene family

0.33 ± 0.05