Figure 1

Enhancement by IL-1β of AMPA- and NMDA-induced currents in rat substantia gelatinosa (SG) neurons. (A) Recordings of AMPA-induced inward currents, which were enhanced in the presence of IL-1β and recovered at 30 min after its washout. Drug application is marked with bars. (B) Recordings of NMDA-induced inward currents, which were enhanced by IL-1β; this enhancement persisted at 30 min after its washout. (C) Bar graphs showing the averaged peak amplitude of AMPA (left, n = 12)- and NMDA (right, n = 7)-induced currents under the treatment with IL-1β (black bar) and after its washout (gray bar), relative to those before this treatment (control, open bar). In this and subsequent figures, vertical lines accompanied by bars indicate SEM; *: P < 0.05, compared with control; n.s.: not significant (t test). In this and subsequent figures, the concentrations of IL-1β used was 10 ng/ml; the concentrations of AMPA and NMDA used were 5 and 50 μM, respectively; the AMPA and NMDA responses were induced at holding potentials (HPs) of −70 and −50 mV, respectively.