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Figure 2 | Molecular Pain

Figure 2

From: Enhancement by interleukin-1β of AMPA and NMDA receptor-mediated currents in adult rat spinal superficial dorsal horn neurons

Figure 2

AMPA- and NMDA-induced current amplitude increase produced by IL-1β was reduced in extent by IR-1ra. (A, B) Recordings of AMPA (A) or NMDA (B)-induced currents in Krebs solution without drugs (left), with IL-1ra (50 ng/ml) alone (middle) and both IL-1ra and IL-1β (right); they were obtained from the same neuron. In each of (A) and (B), all recordings were obtained from the same neuron. (C) Peak amplitude of AMPA (left, n = 8)- and NMDA (right, n = 9)-induced currents in Krebs solution containing IL-1ra only (black bar) and together with IL-1β (gray bar), relative to those without IL-1ra and IL-1β (control, open bar).

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Molecular Pain

ISSN: 1744-8069

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