Figure 2

Alternative behavior measures in a low back pain model. A: Inflammation of the L5 DRG (LID model) resulted in prolonged hypersensitivity of the ipsilateral paw as measured with the von Frey test; control animals all failed to respond to the maximum stimulus applied throughout the testing period. B: reduction in rearing behavior when the rat was placed in a novel chamber, measured 3 days after DRG inflammation. Data in A and B adapted from reference [16]. C: rats (n = 6) took a larger number of shorter steps to cross a wire grid after DRG inflammation, measured 1 day after DRG inflammation, an effect that was reversed by oral naproxen (30 mg/kg given 2 hours prior to testing). *, p < 0.05, **, p < 0.01, ***, p < 0.001 significant difference between the indicated values (ANOVA).