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Table 5 Association of combined COMT/OPRM1 genotypes with pain score in CPP patients

From: Chronic pain after lower abdominal surgery: do catechol-O-methyl transferase/opioid receptor μ-1 polymorphisms contribute?

  

Combined genotypes COMT/OPRM1

  

Met158Val (GA)/A118G (n = 2)

Val158Val (GG)/A118A (n = 10)

Met158Val (GA)/A118A (n = 14)

Met158Met (AA)/A118A (n = 7)

Pain Score

Adjusted mean (95% CI)*

6.4 (4.6, 8.2)

3.4 (2.5, 4.2)

3.3 (2.6, 4.0)

4.0 (3.1, 5.0)

Difference (95% CI), P-value

Reference

−3.0 (−5.1, -1.0), 0.005

−3.1 (−5.1, -1.0), 0.005

−2.4 (−4.5, -0.3), 0.029

Duration of Pain

Adjusted mean (95% CI)*

12.1 (−6.5, 30.7)

15.4 (6.8, 24.0)

14.3 (7.0, 21.6)

10.3 (0.2, 20.4)

 

Difference (95% CI), P-value

Reference

3.3 (−17.2, 23.9), 0.74

2.2 (−18.7, 23.1), 0.83

−1.7 (−23.3, 19.8), 0.87

  1. *: Adjusted least square means after adjusting for baseline pain, pain medication, score age, gender. No significant difference in either pain.
  2. score, or duration of pain among Val158Val (GG)/A118A, Val158Val (GG)/A118A, and Val158Val (GG)/A118A.