Figure 2

Differential endocannabinoid modulation of nociceptive vs. non-nociceptive synapses. (A) Sample traces from experiments using nociceptive (N-to-L, left) and non-nociceptive (P-to-L, right) synapses. Top EPSP traces are from control experiments in which pre- and post-test recordings (black and grey traces, respectively) were made 75 mins apart without 2AG treatment. Middle EPSP traces are from experiments in which pre- and post-test recordings were made in 2AG-treated ganglia. Bottom traces are action potentials from the presynaptic N-cell (left) or P-cell (right). Vertical calibration bar is 2mV EPSP traces and 50 mV for action potential traces. Horizontal calibration bar is 50 msec for all. (B) Bar graph showing that 2AG depressed the N-to-L synapse, but potentiated the P-to-L synapse. (C) Bar graph showing that 2AG depressed the N-to-AP synapse, but potentiated the P-to-AP synapse. Asterisks indicate statistically significant difference relative to the vehicle control group (see Results section for details).