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Figure 4 | Molecular Pain

Figure 4

From: Differential modulation of nociceptive versus non-nociceptive synapses by endocannabinoids

Figure 4

Opposing effects of GABA on nociceptive vs. non-nociceptive afferents and their synapses. (A) Response of nociceptive (N-cell) and non-nociceptive (P-cell) afferents to GABA. GABA elicited depolarization in the N-cells and hyperpolarization in the P-cells (scale bars are, respectively, 2 mV/500 msec and 0.5 mV/1000 msec). Both responses were inhibited by subsequent treatment 15 mins with bicuculline (100 μM) and this decrease was not observed when a 15 mins saline treatment was used in place of bicuculline. (B) Acute bicuculline treatment depresses the nociceptive (N-to-L) synapse, but enhances the non-nociceptive (P-to-L) synapse. Scale bars are, respectively, 2 mV/50 msec and 5 mV/50 msec. Asterisks indicate statistically significant difference relative to the vehicle control group (see Results section for details).

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