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Figure 1 | Molecular Pain

Figure 1

From: An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model

Figure 1

Biosynthesis of LPA following nerve injury by MALDI-TOFMS using Phos-tag. (a and b) Representative charts of mass spectra with internal standard 17:0 LPA (panela ), and mixed standard reagents 16:0, 18:0 and 18:1 LPA as well as internal control (panelb ) at the level of 0.2 nmol, following the use of Phos-tag. (c  and d) Mass spectra of LPA extracts from the contralateral (panelc ) and ipsilateral (paneld ) dorsal half of spinal cord at 3 h after nerve injury. “UI” represents the unidentified compound. (e) Levels of produced LPA species (18:1, 16:0, 18:0 LPA) in spinal cord preparations of control or injured mice. The capital letter “C” represents the control group (naive mice). Data represent means ± SEM from experiments using 3-8 mice. *p < 0.05, versus with the control group.

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