Figure 7

Resveratrol but not PME inhibits AITC-induced pain behavior. Resveratrol (RES, 300 μM, 50 μl) or PME (300 μM, 50 μl) was pre-treated subcutaneously 5 min before AITC (3% in 50 μl liquid paraffin) or vehicle (VEH) injection. A, C: Time course of the number of paw flinches (A) or duration of paw licks (C) induced by AITC or VEH after resveratrol or PME pretreatment, respectively. The number of flinches and duration of licks were counted per 5 min interval in the initial 30 min period after AITC injection. * p < 0.05, ** p < 0.01, versus VEH + AITC (one-way ANOVA followed by Fisher’s PLSD); # p < 0.05, versus VEH + AITC group (two-way repeated ANOVA followed by Fisher’s PLSD). B, D: Cumulative number of paw flinches (B) or duration of paw licks (D) in the initial 30 min period after AITC - or VEH - injection. $ p < 0.05, versus VEH + AITC, (one way ANOVA followed by Fisher’s PLSD). Numbers in parentheses indicate number of rats used in each group.