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Figure 1 | Molecular Pain

Figure 1

From: Effect of amitriptyline on tetrodotoxin-resistant Nav1.9 currents in nociceptive trigeminal neurons

Figure 1

Whole-cell patch clamp recording of TTX-r Na v 1.9 currents in acute isolated TG neurons. A: The protocol to elicit Nav1.9 currents, starting from a holding potential of −70 mV to the prepulse potential of −100 mV, and then to the voltage steps ranging from −80 to −20 mV in increments of +5 mV. B: Representative recordings of the Nav1.9 currents elicited by a series of voltage steps using the protocol in (A). C: Current/voltage (I/V) relationship of Nav1.9 channels with the protocol in (A). Each point was normalized to the amplitude of Nav1.9 currents at −35 mV (n = 9) D: The protocol of a single pulse from −100 mV to −35 mV. E: Peak amplitudes of Nav1.9 currents elicited by a single pulse at −35 mV between 5 and 15 min after whole cell activation was performed. The currents were stable during the recording time in all cells (n = 8).

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