Table 3 Top candidate SNPs selected after final stage analysis in 3-stage GWAS targeting all SNPs (dysesthesia)

Trend

1

rs6829274

4

36167210

4.852

0.0276

6.571

0.0104

5.444

0.0196

0.6536

16.91

3.91E-05

12/65/72

29/83/42

FLJ16686

Trend

2

rs945877

1

197785628

6.571

0.0104

4.92

0.0266

4.828

0.028

0.6536

16.84

4.07E-05

45/74/30

24/69/61

LOC647202

Trend

3

rs2677879

18

2537500

4.078

0.0435

6.071

0.0137

6.585

0.010

0.6536

16.56

4.72E-05

13/51/84

28/73/51

METTL4

Trend

4

rs7825569

8

70057575

5.909

0.0151

6.756

0.0093

3.846

0.0499

0.7411

15.31

9.14E-05

42/77/30

21/76/57

C8orf34

Trend

5

rs1064108

14

64470018

4.777

0.0288

5.124

0.0236

4.78

0.0288

0.653

15.01

0.000107

31/63/55

8/66/80

CHURC1

Trend

6

rs11817730

10

9934850

4.651

0.031

3.85

0.0498

6.73

0.0095

0.6536

14.48

14.48

1/13/135

4/37/113

C10orf65

Trend

7

rs12603925

17

14929712

4.248

0.0393

4.005

0.0454

4.268

0.0388

0.7411

12.29

0.000456

20/66/62

39/74/38

LOC44178

Dominant

1

rs2210585

20

10077600

7.653

0.0057

4.356

0.0369

6.442

0.0111

0.816

17.94

2.28E-05

24/90/35

15/67/72

SNAP25

Dominant

2

rs2677879

18

2537500

3.905

0.0481

5.79

0.0161

6.669

0.0098

0.816

16.31

5.37E-05

13/51/84

28/73/51

METTL4

Dominant

3

rs10805209

4

8600745

6.282

0.0122

4.376

0.0365

4.474

0.0344

0.816

13.72

0.000212

28/68/53

47/81/26

GPR78

Dominant

4

rs6477523

9

108304897

4.762

0.0291

4.356

0.0369

4.151

0.0416

0.816

13.59

0.000228

25/89/35

32/55/67

LOC644620

Recessive

1

rs1567375

11

119007687

5.911

0.0151

9.524

0.002

4.67

0.0307

0.4279

19

1.31E-05

35/67/47

9/81/64

PVRL1 ^✝

Recessive

2

rs4902304

14

64189429

9.896

0.0017

4.376

0.0365

4.149

0.0417

0.4279

17.32

3.15E-05

10/79/60

37/67/50

PLEKHG3

Recessive

3

rs6982411

8

135076849

6.562

0.0104

5.275

0.0216

3.977

0.0461

0.4279

15.69

7.46E-05

17/52/80

1/58/95

LOC729395

Recessive

4

rs730545

5

180446073

4.072

0.0436

4.057

0.044

7.119

0.0076

0.3997

15.55

8.05E-05

18/96/34

47/64/41

BTNL9

Recessive

5

rs10837504

11

40775682

4.595

0.0321

3.852

0.0497

5.934

0.0149

0.4279

14.19

0.000165

2/70/77

19/59/76

LRRC4C

Recessive

6

rs7551844

1

53833921

5.176

0.0229

4.631

0.0314

3.916

0.0478

0.4279

13.7

0.000214

20/89/40

48/70/36

GLIS1

Recessive

7

rs236008

16

6981244

4.062

0.0439

4.174

0.0411

5.273

0.0217

0.4279

13.43

0.000248

15/49/85

1/63/90

HYDIN

Recessive

8

rs2838271

21

43586302

4.595

0.0321

4.174

0.0411

4.362

0.0368

0.427

13.15

0.000288

2/58/89

18/56/80

LOC727743

Recessive

9

rs10497603

2

183044713

4.594

0.0321

4.019

0.045

3.915

0.0479

0.4279

12.08

0.000511

16/55/78

2/67/85

PDE1A