Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy

Table 5 Top candidate SNPs selected after second stage analysis in 3-stage GWAS targeting nonsynonymous SNPs (dysesthesia)

Model	Rank	SNP	CHR	Position	1st stage		2nd stage		Final stage			Combined		Genotype		Related gene
Model	Rank	SNP	CHR	Position	X ²	P	X ²	P	X ²	P	Q	X ²	P	Abnormal	Normal	Related gene
Trend	1	rs2677879	18	2537500	4.078	0.0435	6.071	0.0137	6.585	0.0103	0.0309*	16.56	4.72E-05	13/51/84	28/73/51	METTL4
Trend	2	rs3803800	17	7403693	7.797	0.0052	4.983	0.0256	0.2319	0.6301	0.6301	7.157	0.007467	20/73/56	6/75/73	TNFSF13
Trend	3	rs3777722	6	167272094	7.531	0.0061	1.063	0.3025	1.063	0.3025	0.4538	4.367	0.03665	20/68/60	11/66/77	RNASET2
Dominant	1	rs2677879	18	2537500	3.905	0.0481	5.79	0.0161	6.669	0.0098	0.0491*	16.31	5.37E-05	13/51/84	28/73/51	METTL4
Dominant	2	rs1047406	8	22626880	7.581	0.0059	4.356	0.0369	0.4674	0.4942	0.4942	10.69	0.001078	10/52/87	13/80/61	PEBP4
Dominant	3	rs11205415	1	247087307	4.237	0.0396	4.381	0.0363	1.34	0.2471	0.4118	10.17	0.00143	23/68/58	28/92/34	LOC727776
Dominant	4	rs2240308	17	60985053	4.246	0.0393	5.061	0.0245	0.7561	0.3845	0.4806	8.659	0.003254	16/74/59	16/51/87	AXIN2
Dominant	5	rs3777722	6	167272094	4.439	0.0351	6.171	0.013	3.221	0.0727	0.1818	2.725	0.09881	20/68/60	11/66/77	RNASET2
Recessive	1	rs3803800	17	7403693	5.97	0.0146	6.008	0.0142	0.0048	0.9445	0.9445	8.762	0.003076	20/73/56	6/75/73	TNFSF13
Recessive	2	rs3213706	11	22837578	4.37	0.0366	7.551	0.006	0.1556	0.6932	0.9445	5.98	0.01447	8/73/68	21/58/75	LOC645581

CHR, chromosome number; Position, chromosomal position (bp); Q, Q value for FDR correction of multiple comparison; Related gene, the nearest gene from the SNP site; *, Significant after FDR correction (Q < 0.05).

ISSN: 1744-8069