Skip to main content

Table 3 Effect of GF109203X (GF) on visceromotor response to phasic ascending colorectal distention over time following exposure to single-prolonged stress (SPS)

From: PKCγ receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats

Group 10 mm Hg 20 mm Hg 40 mm Hg 60 mm Hg
Control (n = 8) 0.055 ± 0.006 0.259 ± 0.013 0.380 ± 0.014$ 0.535 ± 0.020$
SPS + Vehicle (n = 7) 0.059 ± 0.007 0.299 ± 0.013 0.670 ± 0.028# 0.896 ± 0.008#
SPS + GF (0.05 nmol) (n = 7) 0.059 ± 0.004 0.293 ± 0.021 0.676 ± 0.012# 0.874 ± 0.010#
SPS + GF (0.15 nmol) (n = 8) 0.059 ± 0.004 0.281 ± 0.017 0.666 ± 0.031# 0.874 ± 0.014#
SPS + GF (0.30 nmol) (n = 8) 0.054 ± 0.004 0.278 ± 0.019 0.584 ± 0.032* 0.856 ± 0.015#
SPS + GF (0.50 nmol) (n = 9) 0.053 ± 0.003 0.277 ± 0.015 0.541 ± 0.014** 0.681 ± 0.018**
  1. All data are expressed as the mean ± S.E.M.
  2. * P < 0.05, and ** P < 0.001, compared with SPS + Vehicle, respectively.
  3. $P < 0.001, compared with SPS + Vehicle.
  4. #P < 0.001, compared with SPS + GF (0.50 nmol).