Skip to main content

Table 3 Effect of GF109203X (GF) on visceromotor response to phasic ascending colorectal distention over time following exposure to single-prolonged stress (SPS)

From: PKCγ receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats

Group

10 mm Hg

20 mm Hg

40 mm Hg

60 mm Hg

Control (n = 8)

0.055 ± 0.006

0.259 ± 0.013

0.380 ± 0.014$

0.535 ± 0.020$

SPS + Vehicle (n = 7)

0.059 ± 0.007

0.299 ± 0.013

0.670 ± 0.028#

0.896 ± 0.008#

SPS + GF (0.05 nmol) (n = 7)

0.059 ± 0.004

0.293 ± 0.021

0.676 ± 0.012#

0.874 ± 0.010#

SPS + GF (0.15 nmol) (n = 8)

0.059 ± 0.004

0.281 ± 0.017

0.666 ± 0.031#

0.874 ± 0.014#

SPS + GF (0.30 nmol) (n = 8)

0.054 ± 0.004

0.278 ± 0.019

0.584 ± 0.032*

0.856 ± 0.015#

SPS + GF (0.50 nmol) (n = 9)

0.053 ± 0.003

0.277 ± 0.015

0.541 ± 0.014**

0.681 ± 0.018**

  1. All data are expressed as the mean ± S.E.M.
  2. * P < 0.05, and ** P < 0.001, compared with SPS + Vehicle, respectively.
  3. $P < 0.001, compared with SPS + Vehicle.
  4. #P < 0.001, compared with SPS + GF (0.50 nmol).