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Table 4 Effect of GF109203X (GF) on abdominal withdrawal reflex score in response to phasic ascending colorectal distention over time following exposure to single-prolonged stress (SPS)

From: PKCγ receptor mediates visceral nociception and hyperalgesia following exposure to PTSD-like stress in the spinal cord of rats

Group 10 mm Hg 20 mm Hg 40 mm Hg 60 mm Hg
Control (n = 8) 1.099 ± 0.120 2.050 ± 0.109 2.588 ± 0.134& 2.850 ± 0.132&
SPS + Vehicle (n = 7) 1.043 ± 0.010 2.100 ± 0.079 3.186 ± 0.083 3.871 ± 0.161
SPS + GF (0.05 nmol) (n = 7) 1.153 ± 0.098 2.071 ± 0.102 3.229 ± 0.068# 3.700 ± 0.115#
SPS + GF (0.15 nmol) (n = 8) 1.030 ± 0.065 2.088 ± 0.048 3.125 ± 0.084# 3.575 ± 0.139#
SPS + GF (0.30 nmol) (n = 8) 1.120 ± 0.087 2.038 ± 0.080 2.825 ± 0.103* 3.700 ± 0.118#
SPS + GF (0.50 nmol) (n = 9) 1.060 ± 0.064 1.967 ± 0.067 2.744 ± 0.100** 3.011 ± 0.353&
  1. All data are expressed as the mean ± S.E.M.
  2. * P < 0.05, and ** P < 0.01, compared with SPS + Vehicle, respectively.
  3. #P < 0.05, compared with SPS + GF (0.50 nmol).
  4. & P < 0.01, compared with SPS + Vehicle.