Table 4 Effect of GF109203X (GF) on abdominal withdrawal reflex score in response to phasic ascending colorectal distention over time following exposure to single-prolonged stress (SPS)

Control (n = 8)

1.099 ± 0.120

2.050 ± 0.109

2.588 ± 0.134&

2.850 ± 0.132&

SPS + Vehicle (n = 7)

1.043 ± 0.010

2.100 ± 0.079

3.186 ± 0.083

3.871 ± 0.161

SPS + GF (0.05 nmol) (n = 7)

1.153 ± 0.098

2.071 ± 0.102

3.229 ± 0.068^#

3.700 ± 0.115^#

SPS + GF (0.15 nmol) (n = 8)

1.030 ± 0.065

2.088 ± 0.048

3.125 ± 0.084^#

3.575 ± 0.139^#

SPS + GF (0.30 nmol) (n = 8)

1.120 ± 0.087

2.038 ± 0.080

2.825 ± 0.103^*

3.700 ± 0.118^#

SPS + GF (0.50 nmol) (n = 9)

1.060 ± 0.064

1.967 ± 0.067

2.744 ± 0.100^**

3.011 ± 0.353&