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Figure 4 | Molecular Pain

Figure 4

From: Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats

Figure 4

Density of sensory fibers in the skin of naïve rats following matrix MMP-2/9 inhibition. The density of CGRP-positive fibers following repeated matrix MMP-2/9 inhibitor (MMP-2/9I.; 10, 20, 40 μg, i.pl.) administration did not change significantly from control levels (C). A and B are representative confocal images of the rat’s glabrous hindpaw skin in vehicle-treated and MMP-2/9 inhibitor (MMP-2/9I.; 20 μg, i.pl.) injected rats, respectively. The results are presented as the mean ± SEM. Inter-group differences were analyzed by ANOVA with a Dunnett’s post hoc test. The dashed line represents the dermal-epidermal junction.

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Molecular Pain

ISSN: 1744-8069

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